Adding to the complexity, Martin falls in love not once, but twice. He eventually marries Leora, whose devotion to him is truly saintly. Martin, however, is only somewhat aware of how fortunate he is. It is through Leora that he makes certain choices and returns to his roots in the laboratory. During this time, he has a significant breakthrough with a substance he names "phage," which leads him to conduct field research and testing in the Caribbean during a bubonic plague outbreak. Tragically, Leora succumbs to the very disease that Martin is striving to cure.
Upon his return home, Martin finds himself thrust into upper society and marries a wealthy woman who gives birth to his only son and builds him an impressive laboratory at home. In exchange, he must attend dinner parties and engage in chit-chat with people he despises. Eventually, Martin decides that his work cannot be interrupted by the trappings of high society or family and moves into the woods with an old colleague. Later, when his wife and son come to him, he rejects them again. It is during this hermit phase that Martin claims he is finally truly working, but I believe he was happiest when he was working in the laboratory with Leora.
It seems that Sinclair Lewis wrote this novel as a social commentary on the changes in American medicine following the 1910 Flexner report, which recommended that medical schools only teach mainstream science. The novel takes Arrowsmith through various career paths, including small-town doctor, professor, researcher, and director. It makes glib references to incompetence, fraud, pseudo-professionalism, and other less-than-ideal aspects of the medical profession (or any profession, for that matter). In some ways, this book reminds me of Robin Williams' speech in Patch Adams about how some doctors are more concerned with their own reputation and a reverence bordering on religious piety than with the profession of humanity.
There were moments when I couldn't help but laugh out loud. Sinclair has a dry wit that, despite being nearly 100 years old, still holds true. However, not all of Arrowsmith's vernacular has aged well, and at times, the meanings are so outdated that the reader must make ignorant guesses. It took me a while to finish this book, and I eventually switched from the Kindle version to the Audible version. Nevertheless, I can't say I didn't enjoy it. I imagine it could be a fun book to read in school, perhaps especially for first-year medical students. In some respects, it even reminds me a bit of another satire, A Confederacy of Dunces. Arrowsmith offers a thought-provoking exploration of the scientific and personal journey of its protagonist, highlighting the challenges and sacrifices that come with the pursuit of truth and the practice of medicine.