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For me, this book was a major disappointment. I truly love Sinclair Lewis. In fact, I even named my dog Babbitt in honor of his book by the same name. However, Arrowsmith left me completely cold. It won the Pulitzer Prize, but for what reason I simply cannot fathom. Personally, I think it was awarded for his body of work rather than this individual book. To me, the book should have been titled, Arrowsmith: A Good Life Wasted. The book has only one redeeming character, Arrowsmith's wife, Leora. She sticks with him through thick and thin, always being at home to lend an ear or a shoulder for him to rest upon. Throughout the book, Arrowsmith is indecisive about his life, his career, and so many other things. He is the epitome of wishy-washy, moving his wife all over the country as his quest for what he really wants to do with his life changes repeatedly. Arrowsmith is a doctor, but he really wants to be an immunologist. However, he lacks the qualifications in chemistry or math to do the job properly. He transitions from being a family doctor to a lab technician and other jobs as he travels across the US. He crosses paths with many people whom he believes are fools, but all of them do extremely well and become influential. Meanwhile, Martin Arrowsmith lives on a meager salary and spends days in his lab conducting tests to find cures for diseases. But once he discovers something, he doesn't publish his results. He wants to study for the sake of the purity of discovery, not realizing that his discoveries could help his employees pay his salary with the profits from the antibodies he works on. The same goes for love. He loves Leora but is constantly looking at other women and going back and forth to the point of being ridiculous. I will end up rating this book 2.5, and that is only because of Lewis' ability to make me want to continue reading about a man whom I have no desire to know or befriend. It's not a fast-paced book and is filled with the typical Boosterism language that is characteristic of the 1920s. The only redeeming part for me was a brief one-page cameo made by George Babbitt, which made me long for Lewis' previous works.