Genetic Entropy & the Mystery of the Genome

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Dr. John Sanford, a retired Cornell Professor, shows in Genetic Entropy and the Mystery of the Genome that the "Primary Axiom" is false. The Primary Axiom is the foundational evolutionary premise - that life is merely the result of mutations and natural selection. In addition to showing compelling theoretical evidence that whole genomes can not evolve upward, Dr. Sanford presents strong evidence that higher genomes must in fact degenerate over time. This book strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process.

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Rating(4.1 / 5.0, 49 votes)
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49 reviews All reviews
April 17,2025
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When doing battle with the White Witch, Edmund gets a kudos from Lewis for being wise enough to attack the witch's wand rather than herself directly. Sanford does something similar here. Most creationists focus on how bad the odds of evolution happening are, and these arguments have already fatally wounded evolutionary theory in times past (e.g. Behe). To be sure, Sanford covers some of the same terrain here, but he spends more time than anyone else thoroughly interrogating "selection" as a force and explaining what it can and cannot feasibly accomplish. The answer, it turns out, is precious little, not even enough to keep genome from actively degenerating.

I found him giving words to problems I had sensed (if not clearly defined) while studying genetics during my undergrad years. For example, he points out there is a severe disjunct between what selection needs to accomplish (fine-tuning miniscule, "near neutral" mutations with little impact on the genome (or organism) overall) and the tools it has to do it (saying "yes" or "no" to the entire genome (or organism)). Most "near neutral" mutations simply don't have enough overall impact to even be seen by selective processes. To compound that problem, differential survival and reproduction is driven much more by random chance ("noise") than by genomic changes overall. When you add the fact that the genome is accumulating bad mutations at a steady rate, you realize that time makes the problem worse, not better. And if you like that argument, read the book, as there's more where that came from.

To address a potential "authority-bluster" counter-argument, even I was initially wondering if this book could really contain any revolutionary arguments since it hasn't made much of a splash. However, I realized the silence shouldn't have surprised me. At this point in history, evolutionary theory has philosophically retreated into it's frozen, academic fortress. Furthermore, secular materialism (the dominant philosophy animating evolutionary theory) is giving it a constant stream of supplies, such that, evolutionary thinking will likely only topple when it does. Either that, or the secularists might come up with a better theory, more worthy of their support. In this kind of climate, it's no wonder that Sanford essentially ended up preaching to the choir, even if he (and I) wish he could do more. To conclude, this really is a stellar book, with some genuinely top-rate, original thinking. I highly recommend it.
April 17,2025
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Sanford delivered concise arguments, supported by published research papers from a wide variety of authors. This is easy to read for the interested layman, and provided lots of new information not captured by other authors like Behe.
April 17,2025
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An interesting book.
Dr. Sanford is clearly very smart, and he knows his material well. And the topic is fascinating, and very possibly supports Sanford's contention that genetic deterioration is the rule in biological systems. But there was, I felt, a lack of accessibility of some of his arguments: too many of the logical links between the data and the conclusions were rushed over. But this is one of the challenges of writing science for the public: sometimes the material itself is difficult. Bottom line: the book is worth reading for exposure to its central thesis, but would have benefited from an editor or two.
April 17,2025
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Very good arguments showing the impossiblity of the typical argument for evolution based on Genetics. Very good read.
April 17,2025
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Best book for Christian apologetics in the field of genetics, or molecular and cellular biology. JC Sanford is a credible and highly recognized scientist who desires the truth and provides source documents and citations to prove that. His work in his field is unprecedented and his book lays out this information for an easy read.
April 17,2025
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There are enough nails in the coffin of evolutionary theory to build a battleship. Dr. Sanford adds several more with this powerful book that discredits the so called Primary Axiom that underpins evolution. The book is reasonably easy to read for anyone with a modest scientific education. Dr. Sanford includes a number of helpful analogies, such as improving a text book and building a space ship.

To illustrate the crumbling support for evolution, the book includes a number of quotes from scientific papers, whose authors delicately try to avoid saying how improbable the entire evolutionary facade is. They sound like they are trying to avoid mentioning the black sheep of the family who turned to a life of crime.

If those in support of evolution wish to respond, this book sets the bar in the field of population genetics.

Dr. Sanford nails his colours to the mast with this book. He deserves much support for it. Highly recommended.
April 17,2025
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This was a thought-provoking book on some often-overlooked aspects of why biological evolution is implausible. It has very high level thinking in it, but as long as you're okay with that, I think you would find it intriguing and helpful. The man who wrote it is a PhD in plant genetics and not directly connected with any official creation organization as far as I can tell, but merely sharing how his own research led him to conclude that evolution, which he had always held to, was impossible.
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